Yak's Bend to Lion's Arch

See http://guildwars.wikia.com/wiki/Beacon%27s_(to_and_from)_Ascalon_City for the ascalon/shiverpeak part of the run and http://guildwars.wikia.com/wiki/Beacon%27s_(to_and_from)_Lion%27s_Arch for the kryta part of the run.

However, the run is so simple nowdays that you don't really need a guide for it. And self-experimentation is how desolation runs are created.