Lion's Arch to Sanctum Cay

Running to the Hot Springs
Hazards: →    →,      → The difficulty of this run is very mild but may still be challenging to anyone not familiar with running through the heavy attack damage put out by Tengus.
 * The more direct paths (marked in Green) will typically only shave a minute or two off the run.
 * Beetletun can also be visited along this route, but adds several minutes to your run-time.
 * Any builds that rely on Enchantments should avoid these direct routes unless they can prevent "shattering" and Phantasm degeneration.

Running to Temple of the Ages
Hazards: →   →  →    In addition to an overabundance of Poison and Crippling (from Ghouls, Rangers, and Bowmasters) in the Cursed Lands, there may also be lots of Blinding being applied. Blind won't affect your running, but will however trigger Fragility damage in high frequency. Right out of the gate, you'll be confronted by these condition spammers and a Necrid Horseman who can easily double the damage you receive from arrows if he hexes you with Barbs.

Before you even reach the entrance to the Cursed Lands, you will also encounter three fairly strong undead groups almost simultaneously. Raw speed and fast crippled-removal spells/shouts are your best allies against these groups. Once inside, the Cursed Lands offers two different paths to take. The first lower path (marked in Green) has no Ghouls, making it optimal for builds with sub-par solutions to Crippling, while the first upper path features a Horseman and several Ghouls, which presents a fairly deadly road-block given the fact that their Crippling Attack has no down-time. After the two trails merge, those runners lacking proper Crippling removal should then follow the upper path (marked in Red) as there will be even more Ghouls near the end of the second lower path. The foes in The Black Curtain will be much more spread-out but will also be higher in level. There is also a constant hazard from Poison being applied simply by stepping in the water there, which is not to be underestimated as it's a gradual but automatic removal of roughly 1/4 of your Health. The Barbs from the patrolling Horsemen can easily be ignored as there are no ranged foes that deal physical damage along that route, but their Desecrate Enchantments can still hit some builds very hard.


 * Tip: Most Blocking skills are very effective at preventing Crippling from Ghouls and Bowmasters.
 * The final upper-path isn't much faster, and also has Bone Dragons along it that can deal lots of damage and interrupts.

Running to Sanctum Cay
Hazards: →  →  →, This is one of the easiest runs in the game, as long as you time your enchants/natural stride (if running on sin) right.

Popular builds
The most popular builds for running this run are listed below: (links go to PvX Wiki)
 * / Build:D/A Unstoppable Drok's Dervish
 * / Build:A/R Shadow Runner
 * / Build:W/any Generic Runner
 * / Build:Any/A General Shadow Forge Runner