Nuke

Nuking is slang for causing great amounts of damage to a number of enemies. This is normally done with using high-damage AoE spells (like Meteor Shower) to take out a group of enemies at once. A player who Nukes is refered to as a Nuker.

Note: The term "nuke" is usually reserved for damaging multiple foes, as opposed to "spike", which means to deal massive damage to a single foe.

Nuke is an obvious, albeit crass, reference to nuclear weapons.