Secondary professions for a Mesmer

Mesmers use the power of a foe against it, and many of their skills disrupt the abilities of enemies. Their focused skills, however, make them highly situational, and are often useless in situations they are not prepared for.

Always remember that when choosing secondary skills, the native skills often have better synergy with the profession's purpose, interact better with the profession's other skills, and benefit from runes.

Mesmer/Warrior

 * Illusionary Weaponry with Flurry provides ample pressure damage. Cyclone Axe can also turn it into Area of Effect damage.

Mesmer/Ranger

 * Illusionary Weaponry with Tiger's Fury / Bestial Fury costs less energy than using Flurry; the loss in damage could be made up with the usage of other Illusion Magic skills.

Mesmer/Monk

 * Because Mesmers have many skills that affect Signets, they can accelerate damage using Smiting Prayers Signets.
 * Re-usable resurrection spells are often beneficial in PvE, and Fast Casting enables them to be used much more quickly. See Rezmer.

Mesmer/Necromancer

 * The Curses attribute has a number of skills which combine nicely with the Mesmer's, such as Reckless Haste which goes well with Empathy. However, Necromancer/Mesmer is generally more effective due to the superior skills and energy management of the Soul Reaping attribute as compared to Fast Casting.
 * However, the PvE-only skill Necrosis is effective on a Mesmer due to a Mesmer's many hexes.

Mesmer/Elementalist

 * Fast Casting can be used to take advantage of some spells with longer casting times in the Elementalist's attributes.
 * High energy spells like Rodgort's Invocation can work well when used with Auspicious Incantation to regain energy quickly.
 * Almost any spell can benefit from the Elementalist's Glyphs.

Mesmer/Assassin

 * Feigned Neutrality and/or Dark Escape can be used while attacking with Illusionary Weaponry, as your attacks never hit. However, the lack of an IAS significantly reduces damage capability, and the double strike chance of daggers is insignificant without investing points in Dagger Mastery.
 * Signet of Twilight can be used for large and cost-free enchantment removal for a Hex-heavy Mesmer.

Mesmer/Ritualist

 * Fast Casting can be combined with damage skills from the Channeling Magic line to provide damage.
 * Repeatable resurrection spells are often beneficial in PvE.

Mesmer/Paragon

 * This profession combination provides little benefit for a Mesmer primary.

Mesmer/Dervish

 * Illusionary Weaponry can be used with defensive skills and cover enchantments from the Earth Prayers attribute. An axe or sword can be used for a faster attack speed, while a scythe can be used to strike multiple targets.