Augury Rock to Dunes of Despair

Running through the desert can be quite hazardous to your health, so I'd suggest a group, or at least bring along henchmen, as many of the groups are very difficult. Anyway, we'll leave from Augury Rock once again, back into Prophet's Path.

Head back towards the teleporter but turn south before reaching it, and you should come to a rather large area of dunes, complete with desert griffons, roamining minotaurs, devourers springing up from the ground, and masses of sand golems. Head south until you can note the southern edge of the map, it is a big impassable hill of sand so it should be hard to miss, then head west.

After a time (this place is quite large so don't rush it) you'll find a turn off into that map edge, which will lead you into the Vulture Drifts past a bunch of sand golems, but, we'll wait just yet on going there, as another 30 seconds west of that is the area called Heroes' Audience, with quests that can turn you into an Elementalist or Necromancer secondary, at least after ascension.

Anyway, into the Vulture Drifts like I said, and of course begin trying to head south. There is little room to move through the first part so when you finally get to an open area where you can actually move in most directions, turn east and follow the southern wall of sand back around to the south until it turns west. Continue heading south around the rocks, until you come across some enchanted armors and such nearby a teleporter, use it, and you merely need to run down the ramp and pull a u-turn to be into the Dunes of Despair.