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It is best to use this on low-health minions to maximize the healing effect of the spell. Using it on a max health minion decreases the ratio of minion health lost to other minion health gained.
Flesh Golem is also a great choice as it leaves a corpse allowing you to summon another one.
This spell combines well with Jagged Bones, as the minion killed will be immediately replaced.
Keep in mind that with Soul Reaping at level 6 or higher, this spell also provides an Energy bonus.
This skill will automatically target the closest minion if none are selected.
Anomaly! Though the Full description implies otherwise, this spell can only be used on minions you control.