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Fragility (sometimes referred to simply as "frag") can be a way to deal damage in a character build. Use it with skills which gives conditions to the enemy, but make sure that the condition lasts for a very short time. For example, one can use Incendiary Arrows or Mark of Rodgort, since they can set the enemy on fire many times for short durations. Virulence is perhaps the most devastating partner spell to use, especially if the linked attribute is low.