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Unlike "conventional" interrupt skills like Power Drain, Guilt preemptively prevents a spell from being cast. In this case, Guilt prevents players from casting spells that would hurt or hinder you or your allies. This can be very useful for when an enemy player is casting spells too quickly to interrupt, or when it is absolutely necessary to stop a player's next spell without risking a missed interrupt. Guilt can punish a player for attempting to damage or hex you without requiring you to time a split-second interrupt.
