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When used with Barrage, Volley or Incendiary Arrows, only the first arrow that hits will induce Poison; this may or may not be the targeted foe. A similar effect occurs when used with skills like Cyclone Axe - only the first foe that is hit will be poisoned.
Combines well with condition-causing preparations like Barbed Arrows. Add Burning Arrow to place massive health degeneration on a single target. This can then be followed up with Epidemic to spread this to your target's allies.
If completed while a projectile is in flight, it will affect that shot and not the subsequent one.