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Through its coordinated use in PvP, this is an effective tool to use when trying to quickly kill a key member of the enemy team, particularly if the enemy team has protection monks.
Does not prevent untargeted enchantments from affecting the target, including self-only enchantments such as Aura of Displacement or party-wide enchantments such as Order of Pain. Also, the target will still have enchantments that were cast before being hexed, but won't be allowed to be targeted for further enchantments.